Fig. 1: Design of copper-dependent supramolecular catalysts inspired by natural catechol oxidases.
From: A supramolecular metalloenzyme possessing robust oxidase-mimetic catalytic function
a Structures of Trametes versicolor laccase (PDB: 1GYC) and ascorbic acid oxidase (PDB: 1AOZ), showing the copper cluster and distributed residues in the active sites. b Schematic self-assembly of nanoaggregates comprising nucleotides (e.g., guanosine monophosphate, GMP), amphiphilic amino acids (e.g., Fmoc-Lysine-OH, Fmoc-K) and Cu2+ ions, that form oxidase-mimetic copper cluster active sites and catalytic activities. Atom colors in the chemical structures: Nitrogen, blue; oxygen, red; phosphorous, green; carbon, dim gray; hydrogen, light gray.
