Fig. 5: The binding affinities between ACE2 orthologs and BA.1, BA.2, a BA.2 mutant harboring the R493Q substitution (BA.2-R493Q) or BA.4/5 RBD. | Nature Communications

Fig. 5: The binding affinities between ACE2 orthologs and BA.1, BA.2, a BA.2 mutant harboring the R493Q substitution (BA.2-R493Q) or BA.4/5 RBD.

From: Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants

Fig. 5

a The SPR curves for the BA.1, BA.2, BA.2-R493Q, and BA.4/5 RBDs binding to ACE2 ortholog in ten species were shown. Raw and fitted curves are represented by red and black lines, respectively. b The statistical table of binding affinities (KD, nM). c A heatmap was used to present the binding affinities. The logarithm of each value (nM) for binding affinity corresponds to the indicated colors. SPR assay was repeated three times with similar results. Source data are provided as a Source Data file.

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