Fig. 3: Viral protein-caused proteinuria in suPAR-Tg mice was SARS-CoV-2 variant-dependent and virus-specific.
From: SuPAR mediates viral response proteinuria by rapidly changing podocyte function
a Inoculation of SARS-CoV-2 2019-nCov nucleocapsid protein in the same scheme as with 2019-nCov S1 protein did not cause proteinuria in male mice with high levels of suPAR (n = 6). P = 0.474, non-significant, two-sided Mann–Whitney test. b Inoculation of SARS-CoV-2 Delta variant (B.1.617.2) S1 protein induced proteinuria in male mice with high levels of suPAR (n = 5). P = 0.0079, two-sided Mann–Whitney test. c Inoculation of SARS-CoV-2 Omicron variant (B.1.1.529) S1 protein in the same scheme as with 2019-nCov S1 failed to elicit proteinuria in male suPAR-Tg mice (n = 6 biological replicates). P = 0.5714, non-significant, two-sided Mann–Whitney test. d Injection of human immunodeficiency virus type 1 (HIV-1) envelop gp120 protein caused proteinuria in suPAR-Tg mice (n = 6, 3 male, 3 female). P = 0.0087, two-sided Mann–Whitney test. e Injection of hepatitis C virus (HCV) E2 protein did not cause proteinuria in suPAR-Tg mice (n = 4, 2 male, 2 female). P = 0.8286, non-significant. f suPAR-Tg mice inoculated with influenza B HA protein did not develop proteinuria (n = 4, male). HA hemagglutinin A. P = 0.6571, non-significant, two-sided Mann–Whitney test. I/N intranasal. I.P intraperitoneal. Data are presented as mean ± SD in all graphs. **P < 0.01.
