Fig. 3: LLS metabolic disease incidence with and without LRC-defined groups. | Nature Communications

Fig. 3: LLS metabolic disease incidence with and without LRC-defined groups.

From: Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Fig. 3

This figure depicts survival curves reflecting metabolic disease incidence within the Leiden Longevity Study (LLS). The x-axis show age in years and the y-axis show metabolic disease incidence. Dotted lines represent the age at which 50% of the members of a specific group had their first metabolic disease. a depicts two groups; the blue line represents LLS Index Persons (IPs; N = 917) and the green line represents the partners (N = 395). The mean difference between the lines represents the Hazard Ratio (HR; estimated effect size) shown in Table 2. b depicts four groups; LRC_g1: IPs with an LRC ≥ 0.60 (dark blue; N = 74), LRC_g2: IPs with an LRC [≥0.1 & <0.60] (light blue; N = 843), LRC_g3: partners with an LRC > 0 (light green; N = 89), and LRC_g4: partners with an LRC = 0 (dark green; N = 262). The mean difference between the LRC_g1-3 and LRC_g4 line represents the HRs shown in Table 3. Vertical lines within the colored lines represent right censored events. The bottom column of panel a and b shows how many persons were still at risk of having a metabolic disease at different ages. Survival curves are adjusted for left truncation and right censoring. Source data are provided as a Source Data file.

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