Fig. 5: Functional differences within the early-life gut microbiome of infants later diagnosed with atopic diseases.

a MaAslin2 volcano plot of Metacyc-annotated gene pathways using predicted age as the outcome, adjusting for chronological age and a random effect of the sample collection site. b 11 pathways associated with predicted age and differential within four or more atopic disease differential analyses (individual or aggregate; FDR < 0.1). c Heatmap of spearman correlation analysis between 11 pathways of interest and nine species identified in Fig. 4.