Fig. 1: Positive association and causality between R. gnavus-derived tryptamine/phenethylamine and insulin resistance in irritable bowel syndrome. | Nature Communications

Fig. 1: Positive association and causality between R. gnavus-derived tryptamine/phenethylamine and insulin resistance in irritable bowel syndrome.

From: Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome

Fig. 1

A–C FBG, TG, and TyG levels in IBS-D patients (n = 290) compared with healthy control (HC, n = 89) subjects (determined by two-tailed t-tests). D, E Spearman’s correlation between relative abundances of R. gnavus and TyG levels in HC and IBS-D subjects (determined by one-tailed test). F, G OGTT and ITT indexes in germ-free mice following colonization of R. gnavus ATCC 29149 (n = 6 per group) (determined by two-tailed t-tests). H, I Tryptamine and phenethylamine levels in serum and fecal samples of germ-free mice following colonization of R. gnavus ATCC 29149 (n = 6 per group) (determined by two-tailed t-tests). J, K OGTT and ITT indexes in antibiotics-treated mice following colonization of either engineered L. casei TDC+ or L. casei WT (n = 6 per group) (determined by two-tailed t-tests). L, M Tryptamine and phenethylamine levels in serum and fecal samples of antibiotics-treated mice following colonization of either engineered L. casei TDC+ or L. casei WT for 3 days (n = 6 per group) (determined by two-tailed t-tests). P values were determined by ordinary two-way ANOVA or Student’s t-test. Data are presented as mean ± S.D. See additional data in Fig. S1.

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