Fig. 2: Impact of omicron infection on plasma neutralizing and binding antibodies in vaccinated SARS-CoV-2-naive and previously-infected individuals. | Nature Communications

Fig. 2: Impact of omicron infection on plasma neutralizing and binding antibodies in vaccinated SARS-CoV-2-naive and previously-infected individuals.

From: Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history

Fig. 2

a Live-virus neutralizing activity of plasma against ancestral, BA.1, BA.2 and BA.5 viruses, expressed as the reciprocal of the dilution showing 50% reduction in focus forming units (FRNT50); b Pair-wise depiction of pre- and post-omicron FRNT as individual participant trajectories for BA.1, BA.2, and BA.5 neutralizing antibodies; c Nucleocapsid-specific IgG in plasma, assessed by ELISA and expressed in WHO International units, BAU/mL; SARS-CoV-2 spike-specific binding IgG (d) and IgA (e) in plasma against ancestral, BA.2 and BA.5 spike proteins (AU/mL = arbitrary antibody units/mL in MSD assay). Data are shown with median and interquartile range. Median fold-change from pre- to post-infection is displayed. Statistical comparisons of paired pre- and post-infection samples made with two-sided Wilcoxon-signed-rank test, and between post-infection levels in previously-infected and SARS-CoV-2 naive individuals made with two-sided Mann–Whitney U-test. P-values are displayed where <0.05. Responses were evaluated in 53 SARS-CoV-2-naive and 37 previously-infected individuals for whom samples were available. Source data are provided as a Source Data file.

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