Fig. 7: ATVCD98hc uptake is enhanced in brain and localize to astrocytes and microglia in cynomolgus monkeys. | Nature Communications

Fig. 7: ATVCD98hc uptake is enhanced in brain and localize to astrocytes and microglia in cynomolgus monkeys.

From: CD98hc is a target for brain delivery of biotherapeutics

Fig. 7

a, b Plasma and brain exposure of mono- and biATVCD98hc6.29:DNP (205 nM KD to cyno CD98hc) EF+ and monoATVCD98hc6.29:DNP EF- in cynomolgus monkeys 4 days after a single 30 mg/kg IV dose. Graphs display mean ± SEM (for n = 2 or 3 as noted in figure) c, d Localization of ATVCD98hc6.29:DNP variations in cortical brain sections assessed by IHC with antibodies against for huIgG (purple) and AQP4 (c, green) or Iba1 (d, green). Scale bars = 30 µm. Overlays are shown with colocalization pseudocolored in white. Representative image shown from n = 3 animals/treatment group (except for biATVCD98hc.6.29:DNP, where one animal was excluded), n = 3 stained sections per animal. Source data are provided as a Source Data file.

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