Fig. 4: Development of a fully biocatalytic platform for asymmetric α-methylation with a record turnover efficiency. | Nature Communications

Fig. 4: Development of a fully biocatalytic platform for asymmetric α-methylation with a record turnover efficiency.

From: A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases

Fig. 4

a Mining of Pseudomonas HMTs: sequence similarity network (SSN) of selected putative HMTs. b Dual biocatalytic enantioselective methylation using SgvMVAV and HMTs mined from Pseudomonas species. PaHMT: P. aeruginosa HMT, PeHMT: P. entomophila HMT, PfHMT: P. fluorescens HMT, PpHMT: P. putida HMT, PsHMT: P. syringae HMT. a0.01 mol% PaHMT was used. c SAM regeneration efficiency with HMTs from Pseudomonas sp.

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