Fig. 4: Antitumor activity of STPNs in vitro. | Nature Communications

Fig. 4: Antitumor activity of STPNs in vitro.

From: Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

Fig. 4

a Schematic illustration of STPNs underlying molecular mechanism. b Western blot for NFκB p65, NFκB p50, β-actin, and Lamin B1 in the cytoplasm or/and nucleus of GBC-SD or EH-GB1 cells exposed to normal media, TZB, SPNs, or STPNs with/without 980 nm laser irradiation (2.0 W cm−2, 5 min with every 1 min interval). c Intracellular ROS observation of GBC-SD or EH-GB1 cells treated as indicated (scale bar = 100 µm). d 48 h CCK-8 assays of GBC-SD or EH-GB1 cells exposed to normal media, TZB, SPNs, or STPNs with/without 980 nm laser irradiation (2.0 W cm−2, 5 min with every 1 min interval). The data are represented as mean ± SD (n = 3 independent experiments, one-way ANOVA and Tukey’s multiple comparison test). **P < 0.01.

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