Fig. 10: Conformational changes of IP-HD during P2X3 receptor channel gating, and schematic diagram of the mechanism of inhibition by quercetin and PSFL2915. | Nature Communications

Fig. 10: Conformational changes of IP-HD during P2X3 receptor channel gating, and schematic diagram of the mechanism of inhibition by quercetin and PSFL2915.

From: Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

Fig. 10

Tightening of IP-HD is essential for P2X3 receptor activation, and quercetin from natural products inhibits P2X3 receptor activation by blocking the tightening of IP-HD. This likely underlies the main mechanism of quercetin and PSFL2915 in cough relief.

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