Fig. 3: Fab-fragments facilitate structural study of OATP1B1 and OATP1B3. | Nature Communications

Fig. 3: Fab-fragments facilitate structural study of OATP1B1 and OATP1B3.

From: Structure of human drug transporters OATP1B1 and OATP1B3

Fig. 3

a EM density map (left) and ribbon representation (right) of the E1S-bound OATP1B1-Fab18 complex. Chains are colored separately and labeled. Fab fragment is also displayed as transparent surface. b EM density map (left) and ribbon representation (right) of bicarbonate-bound OATP1B3-Fab19 complex. The representation is shown as in (a). c Close-up views on binding epitopes of Fab18 (left) and Fab19 (right). The residues within 4.0 Å are displayed as sticks and labeled. An ordered cholesterol molecule is shown as grey sticks.

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