Fig. 7: Passive protection by the long-term immunity sera. | Nature Communications

Fig. 7: Passive protection by the long-term immunity sera.

From: mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge

Fig. 7

Naïve mice were intravenously injected with 100 µL of sera obtained from the long-term immunity group, which contained an equal-volume mixture of sera collected from months 1–4 post vaccination. The following day, the mice were intranasally challenged with 1 × 105 PFU VACV-WR. The mean body weight change post virus infection (a) and body weight changes for individual animals were recorded and analyzed for DPBS (b), VGPox 1 (c), VGPox 2 (d), VGPox 3 (e), and VACV (f). n = 4 biologically independent mice. Comparison between DPBS and VGPox2 on day 8 and day 9 were analyzed by two-tailed t-test. “*” indicates p < 0.05.

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