Fig. 4: Hazard ratios (95% confidence intervals) for all-cause mortality by heteroplasmy and mutation type. | Nature Communications

Fig. 4: Hazard ratios (95% confidence intervals) for all-cause mortality by heteroplasmy and mutation type.

From: Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Fig. 4

a Hazard ratios (HR) for the association of all-cause mortality by heteroplasmy count, presence of synonymous mutation, nonsynonymous mutation, nonsense mutation, and MLC score sum (MSS) were estimated from separately Cox proportional hazards models stratified by assessment center and adjusted for age, sex, and smoking status. The numbers of participants and events reflects the number included in the regression analysis. b Adjusted dose-response relationship between MSS and all-cause mortality and histogram of MSS among participants with at least 1 heteroplasmy count. Hazard ratios (95% confidence intervals) were derived from Cox proportional hazards models that include MSS as restricted cubic splines with 4 degrees of freedom and were stratified by assessment center and adjusted for age, sex, smoking status, alcohol intake, body mass index, white blood cell count, and haplogroup. 58 participants with MSS greater than 2 were excluded from the plot. Source data are provided as a Source Data file.

Back to article page