Table 1 Baseline demographic, laboratory, and clinical characteristics
 | Pooled placebo (N = 9) | ZSP1601 | |||
---|---|---|---|---|---|
50 mg QD (N = 9) | 50 mg BID (N = 9) | 100 mg BID (N = 9) | |||
Age, years | 37.0 (32.0–40.0) | 34.0 (31.0–36.0) | 28.0 (25.0–38.0) | 30. 0 (24.00–38.0) | |
Sex | Male | 5 (55.6) | 9 (100) | 8 (88.9) | 7 (77.8) |
Female | 4 (44.4) | 0 (0) | 1 (11.1) | 2 (22.2) | |
Ethnicity, Asian (Chinese) | 9 (100) | 9 (100) | 9 (100) | 9 (100) | |
Liver chemistries | ALT, U/L | 95.33 (21.12) | 90.89 (15.11) | 106.70 (22.94) | 132.34 (62.29) |
AST, U/L | 49.46 (12.55) | 41.19 (8.22) | 56.64 (16.69) | 68.46 (31.55) | |
ALP, U/L | 79.49 (23.10) | 64.08 (22.05) | 103.97 (36.76) | 96.41 (20.51) | |
GGT, U/L | 93.88 (44.08) | 66.19 (34.13) | 116.61 (84.35) | 84.76 (39.96) | |
LFC, % | 24.39 (10.77) | 21.24 (7.75) | 21.00 (6.03) | 20.99 (9.05) | |
Noninvasive biomarkers | CAP, dB/m | 329.00 (28.31) | 337.33 (29.08) | 318.89 (44.56) | 321.63 (41.85) |
LSM, Kpa | 7.11 (1.66) | 6.51 (2.41) | 8.69 (6.63) | 6.53 (2.46) | |
FIB4 | 0.72 (0.33) | 0.62 (0.36) | 0.76 (0.35) | 0.69 (0.30) | |
APRI score | 0.49 (0.17) | 0.41 (0.14) | 0.59 (0.19) | 0.64 (0.33) | |
FAST score | 0.52 (0.09) | 0.48 (0.16) | 0.51 (0.24) | 0.53 (0.17) | |
Lipids | TG, mmol/L | 2.92 (1.37) | 3.16 (2.08) | 3.95 (2.31) | 1.92 (0.83) |
TC, mmol/L | 5.25 (1.06) | 4.76 (1.07) | 5.83 (0.94) | 5.24 (0.89) | |
LDL-C, mmol/L | 3.46 (0.78) | 2.90 (0.88) | 3.88 (0.90) | 3.43 (0.72) | |
HDL-C, mmol/L | 1.13 (0.24) | 1.15 (0.30) | 1.15 (0.22) | 1.17 (0.23) | |
Blood glucose, mmol/L | 6.22 (1.08) | 5.64 (1.52) | 5.64 (0.57) | 6.00 (0.95) | |
Blood insulin, μU/mL |  | 128.23 (104.46) | 112.08 (64.13) | 139.08 (73.66) | 151.50 (83.30) |
Inflammatory cytokines | TNF-α, pg/mL | 0.86 (0.26) | 0.74 (0.17) | 0.92 (0.30) | 0.64 (0.20) |
IL-6, pg/mL | 3.27 (1.82) | 1.64 (0.72) | 2.19 (2.40) | 2.37 (1.65) | |
IP-10, pg/mL | 125.82 (61.30) | 51.81 (35.55) | 80.49 (52.20) | 115.77 (47.41) | |
CK-18, pg/mL | 1008.56 (1283.75) | 509.70 (218.71) | 1509.87 (1390.87) | 810.53 (632.73) | |
Obesity parameters | Body weight, kg | 81.02 (8.94) | 83.92 (8.15) | 85.96 (13.19) | 81.10 (12.33) |
BMI, kg/m2 | 29.47 (3.57) | 29.03 (2.76) | 30.32 (2.89) | 28.38 (3.04) | |
Waist circumference, cm | 99.80 (6.96) | 102.03 (6.83) | 100.12 (5.77) | 97.02 (11.15) | |
Abdominal circumference, cm | 102.23 (7.33) | 102.73 (6.94) | 101.22 (8.03) | 98.16 (11.76) |