Fig. 1: Overall structure of human SLC15A4/TASL complex.
From: Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
a, b 3.0-Å-resolution cryo-EM map (a) and ribbon model (b) of human SLC15A4-TASL complex. SLC15A4 and TASL are colored blue and yellow, respectively. The N-436 glycosylation is shown as sticks. c Topology diagram of human SLC15A4/TASL(1–20)-EGFP complex. TM helices and beta strands of SLC15A4 and the N-terminal sequence of TASL are schematically illustrated. The SLC15A4 and TASL are colored blue and yellow, respectively. d Left: Heatmap of the surface electrostatics of human SLC15A4 shows a TASL-binding pocket. TASL is shown as a yellow cartoon. Right: Close-up view of the binding interface between SLC15A4 and TASL. Potential hydrogen bonds are indicated with red dotted lines.
