Fig. 1: Schematic workflow of collecting and annotating E3 ligases. | Nature Communications

Fig. 1: Schematic workflow of collecting and annotating E3 ligases.

From: Expanding PROTACtable genome universe of E3 ligases

Fig. 1

a Illustration of collecting and scoring E3 ligases in inner circle, while the distribution of scores of E3 ligases and co-opted E3 ligases in outer circle. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were explored in PROTAC experiment. b We comprehensively characterized E3 ligases chemical ligandability, expression patterns, protein–protein interactions (PPI), structure availability, functional essentiality, cellular ___location, and PPI interface. Created with BioRender.com.

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