Fig. 3: The expression landscape of E3 ligases in tumors. | Nature Communications

Fig. 3: The expression landscape of E3 ligases in tumors.

From: Expanding PROTACtable genome universe of E3 ligases

Fig. 3

a Expression of E3 ligases in TCGA. Left side barplot showing the number of E3 ligases highly expressed in the cancer types of TCGA. Top barplot showing the number of highly expressed cancer types of the E3 ligases. b Expression of E3 ligases in HPA pathology. Left side barplot showing the number of E3 ligases highly expressed in the cancer types of HPA pathology. Bottom barplot showing the number of highly expressed cancer types of the E3 ligases. c Expression of E3 ligases in BRCA cancer type at single-cell level. Pie plot showing the distribution of cells expressing E3 ligases. Dot plot showing the percentage and level of cells expressed E3 ligases within the cell type. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were experimentally explored in PROTAC.

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