Fig. 5: Characterization of PPIs between E3 ligases and targets. | Nature Communications

Fig. 5: Characterization of PPIs between E3 ligases and targets.

From: Expanding PROTACtable genome universe of E3 ligases

Fig. 5

a, b PPIs between E3 ligases and targets. c PROTAC tractable targets highlighted in the PROTACtable genome and MAPD in human genome. d Interactions between E3 ligases and PROTAC tractable cancer targets. Top barplot showing the number of targets interacting with E3 ligases. Left and right side barplot showing MAPD score of targets. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were experimentally explored in PROTAC experiment.

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