Fig. 6: Structure availability, functional essentiality, and cellular ___location of E3 ligases. | Nature Communications

Fig. 6: Structure availability, functional essentiality, and cellular ___location of E3 ligases.

From: Expanding PROTACtable genome universe of E3 ligases

Fig. 6

a Distribution of the number of available structures of E3 ligases. b The number of protein structures of E3 ligases. c, d Distribution of mean of the probability of essentiality of E3 ligases by CRISPR and RNAi. e Ridgeplot showing the distribution of tumor-essential E3 ligases in both datasets. f Sankey plot showing cellular localization of E3 ligases from different data sources. g The cellular localizations of E3 ligases. h Outer ring showing E3 ligases with available PPI interface and inner ring showing the distribution of origins of PPI interface. i E3 ligases with top number of PPI interfaces. E3 ligases in red were proceeded to PROTAC clinical trials. E3 ligases in blue were experimentally explored in PROTAC experiment.

Back to article page