Fig. 7: In vivo experiments confirm the regulatory effects of RNF13 on STING in NASH. | Nature Communications

Fig. 7: In vivo experiments confirm the regulatory effects of RNF13 on STING in NASH.

From: RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways

Fig. 7

a Schematic depiction of the in vivo rescue experiments. b The protein level of RNF13, STING, p-P65/P65, IκBα and p-TBK1/TBK1 in the livers of the mice from the indicated groups (n = 3). Body weights (c), blood glucose levels (d), GTT assays (e) and the corresponding AUC (f), liver weights (g), ratios of liver weight to body weight (h), serum TG (i), serum TC (j), liver TG (k), serum ALT (l) and AST levels (m) of the mice from the indicated groups (n = 8). H&E (n), Oil Red O (o), CD11b (p) and Masson (q) staining and corresponding quantification of liver sections of the mice from the indicated groups (n = 6). Scale bars, 100 μm. Data were expressed as mean ± SD. One-way ANOVA with Bonferroni post hoc analysis for c, d, and f–q, two-way repeated-measures ANOVA followed by Bonferroni post hoc analyses for e (Upper p-value for comparison between Rnf13-overexpressed/OE group and the control group; Lower p-value for comparison between Rnf13-OE group and Rnf13&Sting1-OE group). Source data are provided as a Source Data file.

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