Fig. 7: Altered transcriptomes of CD8+ T cells against nucleocapsid LLL epitope in non-expanders. | Nature Communications

Fig. 7: Altered transcriptomes of CD8+ T cells against nucleocapsid LLL epitope in non-expanders.

From: SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Fig. 7

a Summary of scRNAseq findings of LLL+ CD8+ T cells (total and TRAV12-2+) from freshly isolated cells (convalescent and uninfected donors) and in vitro stimulated cells (convalescent only). b UMAPs shows the subsets composition of LLL+ CD8+ T cells from expanders and non-expanders. c Enriched expressed genes in CD8+ T cells and subsets of non- expanders heatmap of selected enriched genes of CD8+ T cells within d0 cells of non- expanders compared to expanders. NES normalized enriched score. it ranges from 0 to 2. d Interactions of enriched expressed genes in CD8+ T cells of non-expanders. Pathway analysis of selected significantly enriched genes in CD8+ T cells of non-expanders in four functional GO groups.

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