Fig. 1: Differential gene expression patterns differ in males and females with MDD, revealing sex- and brain region-specific transcriptional profiles.
From: Transcriptional dissection of symptomatic profiles across the brain of men and women with depression
a Venn diagrams of DEGs (nominal p < 0.05; two-tailed) showing low overlap between male MDD (blue) and female MDD (pink) across brain regions. b RRHO maps displaying transcriptional overlaps between male MDD and female MDD across brain regions. Signals in the bottom left and upper right quadrants represent an overlap for commonly upregulated and commonly downregulated genes, respectively. The color bar represents the degree of significant (−log (padj-value); FDR corrected; two-tailed) overlap between transcriptional signatures in males and females with MDD. c Bubble plot showing the most variable genes differentially expressed in male MDD and female MDD across six brain regions. Colors represent log fold change values, with blue for genes downregulated and yellow for genes upregulated in MDD versus control conditions. The radius of the circles shows significance levels according to their p-values (nominal p < 0.05; two-tailed). d RRHO maps representing transcriptional overlaps between the new cohort sequenced in this paper and a previously published cohort27. Source data are provided as a Source Data file.
