Fig. 1: Biologically active compounds containing 2-substituted tetrahydrofuran skeletons. | Nature Communications

Fig. 1: Biologically active compounds containing 2-substituted tetrahydrofuran skeletons.

From: Mechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes

Fig. 1

Substructures colored in blue highlight the core 2-substituted tetrahydrofuran skeleton with stereocenter. Zidovudine, an antimetabolite and a HIV-1 reverse transcriptase inhibitor. ALS−8112, respiratory syncytial virus (RSV) polymerase inhibitor. Magnofargesin, a natural product found in Magnolia biondii. Fijianolide A, a natural compound isolated from Spongia mycofijiensis. Ophiobolin A, a fungal secondary metabolite has activity against glioblastoma. Amphidinolide X, a natural product isolated from Amphidinium sp.

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