Fig. 8: Enhanced levels of PTX3 are associated with disease severity of childhood allergic asthma. | Nature Communications

Fig. 8: Enhanced levels of PTX3 are associated with disease severity of childhood allergic asthma.

From: RNA m6A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis

Fig. 8

The PTX3 mRNA levels in monocyte-derived macrophages (a) and protein levels in the plasma (b) were measured in 55 childhood allergic asthma and 50 healthy controls using RT-qPCR and ELISA, respectively. c RT-qPCR showing elevated levels of STX17 in monocyte-derived macrophages from 55 childhood asthma population. The detailed minimum, median, maximum, 25th, 75th percentile (box), and 5th and 95th percentile (whiskers) of box plots were provided in the Source data file. d ROC curve analysis of PTX3 protein levels in 55 childhood asthma. e Spearman correlation (two-sided) analysis between PTX3 protein levels in plasma and blood eosinophils numbers, or FeNO in 55 childhood allergic asthma. f Proposed working model of m6A-controlled macrophage homeostasis in allergic asthma (Schematic created with BioRender.com). Statistical analysis of the data was performed using two-sided unpaired t test (b), or Mann–Whitney test (a, c). Data are presented as means ± SEM. **P < 0.01, ****P < 0.0001.

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