Fig. 4: Validation using Wilms tumor (WT) cell lines and primary cultures.
From: Delineating the interplay between oncogenic pathways and immunity in anaplastic Wilms tumors
a Heatmap showing enrichment scores of oncogenic pathways in 12 WT cells/patient-derived xenograft (PDX)/primary-cultures. b Boxplot showing enrichment score of EZH2 partners between iWT (n = 8) and dWT (n = 4) in GEO-WT dataset using two-sided Mann-Whitney test; the center line represents the median, box hinges represent first and third quartiles and whiskers represent ± 1.5× interquartile range. c Transcriptomic similarity between SFCE-WT subtypes and WT cells/PDX/primary-cultures histology using subclass mapping. Bonferroni and Benjamini-Hochberg correction (false discovery rate, [FDR]) methods were used to adjust P-values. d Venn diagrams with representation factor (RF) revealing significant overlapping of the differentially expressed genes in dWT versus iWT subtypes between SFCE-WT and GEO-WT datasets. Source data are provided as a Source Data file.
