Fig. 4: Association of HFpEF-related eicosanoids and eicosanoid-related metabolites (from MGH CPET) with incident HF in MESA. | Nature Communications

Fig. 4: Association of HFpEF-related eicosanoids and eicosanoid-related metabolites (from MGH CPET) with incident HF in MESA.

From: Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Fig. 4

Eicosanoids and eicosanoid-related metabolites chosen for analysis in MESA were significantly associated with HFpEF status in the MGH CPET cohort. Hazards ratios displayed represent hazards of developing HF per 1-SD increase in log-transformed eicosanoid and related metabolite in MESA. Data presented are HR (dots) with 95% confidence intervals (bars). Analyses are adjusted for age, sex, site, and plate number. p-value threshold < 0.05 considered significant based on Cox regression models. Eicosanoids and eicosanoid-related metabolites with directionally consistent associations in both the MGH CPET and MESA samples are denoted in red. Eicosanoids and eicosanoid-related metabolites with directionally discordant associations in the MGH CPET and MESA samples are denoted in gray. *denotes putative eicosanoid metabolite. **denotes putative eicosanoid-related metabolite. CI confidence interval, HF heart failure, ALA alpha-linoleic acid, LA linoleic acid. Source data are provided as a Source Data file.

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