Fig. 5: Bispecific CAR T cells have high transduction efficiency and high binding of soluble antigen.
From: Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma
a Schematic of bispecific CAR T cell vector design. b Model of tandem scFv CAR T cells. c Transduction efficiency of dual-targeting CARs (n = 3ND). Binding of soluble BCMA (d) or TACI (e) to bispecific CARs at the indicated concentrations measured by flow cytometry (n = 3ND+/– SEM). Binding at 10 nM shown below for simplicity (one way ANOVA compared using anti-BCMA or anti-TACI L-H CARs as controls accordingly). Raw data is provided in the Source Data file. All tests are two-sided. p = ****<0.0001.
