Fig. 5: Electrocorticogram features and seizure propensity in Cav2.3 phosphomutant mice. | Nature Communications

Fig. 5: Electrocorticogram features and seizure propensity in Cav2.3 phosphomutant mice.

From: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Fig. 5

a left: two-week baseline ECoG spectral analysis and total power (inset) in WT (n = 8) and HOMS15A (n = 10) 9–12 week-old mice; corresponding coastline index (middle) and kurtosis (right) (p > 0.05, Two-Way ANOVA and two-tailed unpaired t tests). No sex differences were observed. b left: behavioural scoring of kainic acid (KA)-induced seizures (WT males n = 3, females n = 4; HOMS15A males n = 4, females n = 6; sex x genotype p = 0.006, Three-Way ANOVA) using repetitive 5 mg/kg i.p. injections (inset); right: latency to stage 5 tonic clonic seizures per gender (two-tailed unpaired t test). c Corresponding cumulative ECoG coastline during KA seizures in females (WT n = 3, HOM S15A n = 4, time x genotype p = 0.018, Two-Way ANOVA). Data is presented as mean ± S.E.M or in box plots representing minimum, maximum, median, 25/75 percentile and mean (indicated by a marker). Source data are provided as a Source Data file.

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