Fig. 1: The principle of the “metal binding targeting” strategy and the development of the CAST conjugation.
From: Copper assisted sequence-specific chemical protein conjugation at a single backbone amide
a The principle of using a “metal binding targeting” strategy to develop a unique peptide sequence for single site-specific chemical protein conjugation. M is a transition metal ion, L is a metal ion ligand, and R-X is a reacting small molecule. b The development procedure of the CAST conjugation.
