Fig. 1: Aβ40 fibrils in the presence of phospholipids.
From: Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
a A negative stain transmission electron microscopy (TEM) micrograph (a representative from a total of 33). b A 20 Å low-pass filtered cryo-electron microscopy (cryo-EM) micrograph of lipidic Aβ40 fibrils (representative from a total of 14,417). The yellow arrows indicate the fibril-bound incomplete liposomes. c The sequence of Aβ40. Residues assigned by NMR are colored blue. d Examples of 2D class averages for L1. The yellow arrows indicate the fibril-bound layers of lipids (incomplete liposomes), lacking the characteristic amyloid cross-β pattern, while the cross-β pattern is evident for the Aβ40 fibrils. e 3D(H)CANH spectrum of lipidic Aβ40 fibrils. Red arrows depict the two populations of K28 and D23.
