Fig. 5: Cryo-EM structures of lipidic L2–L3, L2–L2, and L3–L3 Aβ40 fibrils.
From: Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
a–c Cross-sections of the cryo-EM maps of the L2–L3 (a), L2–L2, (b), and L3–L3 (c) Aβ40 fibrils, with lipid densities indicated by a yellow arrow. d–f Overlays of a sharpened high-resolution map and an unsharpened, 4.5 Å low-pass filtered density are shown in gray for the L2–L3 (d), L2–L2, (e), and L3–L3 (f) Aβ40 fibrils. The close-up view shows areas with pronounced lipid densities, with ring-shaped densities in the cryo-EM cross-sections showing the lipid head groups, while the rod-shaped densities show the lipid acyl chains. Supplementary Fig. 8d–f shows the sharpened high-resolution maps at different isosurface levels.
