Fig. 9: TFs are responsible for heterogeneous response under hypoxia treatment.
From: Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
a UMAP plot of integration of scATAC-seq under normoxia and scRNA-seq with hypoxia treatment of DLD-1 (left). UMAP plot of scRNA-seq of DLD-1 upon hypoxia treatment (right). b The activity of ETS (ELK4, FLI1) and E2F (E2F3, E2F6) family TFs across clusters in DLD-1. c UMAP plot of integration of scATAC-seq under normoxia and scRNA-seq with hypoxia treatment of SW620 (left). UMAP plot of scRNA-seq of SW620 upon hypoxia treatment (right). d The activity of HMG (TCF4, TCF3) family TFs across clusters in SW620. Source data are provided in the Source Data file.
