Fig. 8: Model of how senescence-associated 13-HODE production promotes age-related liver steatosis. | Nature Communications

Fig. 8: Model of how senescence-associated 13-HODE production promotes age-related liver steatosis.

From: Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity

Fig. 8

Increased ALOX15 in senescent hepatocytes and macrophages produces more 9-HODE and 13-HODE. Increased 13-HODE acts on the hepatocytes surrounding the senescent hepatocytes, binding to CAT and decreasing CAT activity. Decreased CAT activity activates SREBP1 further by increasing H2O2 levels and promoting liver steatosis. The illustration was created with Biorender.com.

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