Fig. 6: Characteristics of tumors that do not recur. | Nature Communications

Fig. 6: Characteristics of tumors that do not recur.

From: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial

Fig. 6

a Pathology response, as percent of cancer cell killing, for tumors without MPR grouped by disease recurrence. Mean ± SEM. No recur (n = 23) and Recur (n = 9). Two-sided, unpaired Mann-Whitney test. b PD-L1 positive cancer cells as percent of total cancer cells determined by IHC for tumors without MPR grouped by disease recurrence. Mean ± SEM. No recur (n = 22) and recur (n = 9) Two-sided, unpaired Mann-Whitney test. c Tumor mutational burden for tumors without MPR grouped by disease recurrence. Mean ± SEM. No recur (n = 11) and recur (n = 6). Two-sided, unpaired Mann-Whitney test. d Heatmap of differentially expressed genes between tumors with or without disease recurrence, excluding tumors that achieved MPR. Solid symbols are from the dual therapy arm. e Some GO pathways enriched among genes upregulated in tumors that did not recur. Percentages of the genes in the gene set that were differentially expressed in the data. Source data for panels (a, b, c, e) are provided as a Source Data file.

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