Fig. 7: Blocking the MAPK/ERK pathway during the activation period prevents compulsive-like behaviors in mice with chronic BLA-DMS activation. | Nature Communications

Fig. 7: Blocking the MAPK/ERK pathway during the activation period prevents compulsive-like behaviors in mice with chronic BLA-DMS activation.

From: Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Fig. 7

a Experimental scheme. SL327 along with CNO was administered for 12 consecutive days after the habituation period. SL327 or saline was administered 15 min before CNO injections. (CNO (+Saline), n = 11; CNO + SL327, n = 5). b–d Behavioral outcomes of co-administration of SL327 with CNO during the activation period (two-way repeated measures ANOVA with post hoc Sidak’s multiple comparisons test, interactionday × drug (checking), F4, 56 = 6.411, P = 0.0003 (b), interactionday × drug (nose pokes), F4, 56 = 5.427, P = 0.0009 (c), interactionday × drug (grooming duration) F4, 56 = 4.283, P = 0.0043 (d)). Box-and-whisker plots display the median (line), 25th and 75th percentiles (box edges), minimum and maximum (whiskers). e Effect of SL327 on reversal test (two-sided paired t-test, CNO, t = 1.455, df = 10, P = 0.1762; SL327 + CNO, t = 6.898, df = 4, P = 0.0023). f The effect of SL327 on hoarding behavior (two-sided Mann−Whitney test, Food pellet, U = 0, P = 0.0005; Beads, U = 1, P = 0.0009).

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