Fig. 8: Working model.
From: Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling
In basal cells of normal mammary gland epithelium, Mcam inhibits, and Ryk promotes MEC proliferation to sustain the homeostasis of mammary gland development. Loss of Mcam promotes the recruitment and activation of macrophages via the Il4-Stat6 axis and thereafter induces Wnt5a secretion by macrophages. The binding of Wnt5a to Ryk, a non-canonical Wnt receptor, elevates regenerative capacity and excessive MEC proliferation. Created with BioRender.com.
