Fig. 3: ECD of ELIC in different nanodiscs scaffolds.
From: Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel
a Global superposition of apo-spMSP1D1ELIC (light blue) and MSP1E3D1ELIC5 (deep purple) with red and blue boxes highlighting the agonist binding site (b) and the β1-β2 and β8-β9 loops (c), respectively. b Loops B and C of the agonist binding site with the distance (Å) between the indicated residues shown for SMAELIC (lime green), MSP1E3D1ELIC (cyan), and spMSP1D1ELIC (gray). Image shows a superposition of the ECD. c Global superposition of structures showing side view of β1-β2 and β8-β9 loops for apo-spMSP1D1ELIC (light blue), SMAELIC (lime green), MSP1E3D1ELIC (cyan), spMSP1D1ELIC (gray), spNW15ELIC (orange), and MSP1E3D1ELIC5 (deep purple). d Top view of an ECD subunit showing the counter-clockwise rotation of apo-MSP1E3D1ELIC (raspberry) compared to MSP1E3D1ELIC (cyan), and apo-spMSP1D1ELIC (light blue) compared to spMSP1D1ELIC (gray). Images show a superposition of the TMD to illustrate rotation of the ECD relative to the TMD.
