Fig. 5: Reconstruction of a high-confidence maize transcriptional regulatory network.
From: Decoding the gene regulatory network of endosperm differentiation in maize
a Summary of the inferred GRN. Network topology parameters are shown. Diam., diameters; Coef., clustering coefficient; *, only regulatory TFs were counted. b Representative key regulators identified by network topology analysis (TFs with top out-degree and betweenness centrality are displayed); the expression patterns of these TFs are shown at right, with colors representing scaled expression values. c The regulatory network of 181 regulons. Cell-type-specific TFs are highlighted in the network. Colors represent the in-degree value determined by network topology analysis. d Distribution of node degree values fits the power law (black lines). e GO enrichments of selected regulons. Predicted target genes of representative TFs were enriched for functional terms associated with biological properties. P-values were obtained using hypergeometric test, with g:SCS (graph-based stratified Cox-Snell) correction applied for multiple comparisons. f, g ROC (f) and precision-recall (g) curves generated using known TF target genes for the coexpression GRN (red) and the integrated regulon GRN (blue).
