Fig. 5: CD8+ T cells expanding after interruption of early treatment express low levels of activation markers. | Nature Communications

Fig. 5: CD8+ T cells expanding after interruption of early treatment express low levels of activation markers.

From: Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells

Fig. 5

Expression levels of CD38 and HLA-DR activation markers (A) and intracellular levels of Ki67 proliferation markers (E) in blood CD8+ T cells during primary SIV infection and post-ATI in W4-treated (n = 11) and W24-treated CyMs (n = 11). Cumulative CD38, HLA-DR (B) and Ki67 (F) expression levels in blood CD8+ T cells during the first 4 weeks following SIV infection and post-ATI. Comparison of CD38 and HLA-DR (C) and Ki67 (G) expression levels in PLN CD8+ T cells between W4- and W24-treated CyMs at the time of cART initiation, 14 days post-ATI and at euthanasia. The results are shown as percent frequencies of CD8+ T cells or AUC; Spearman correlation between cumulative (AUC) CD38 and HLA-DR (D) and Ki67 (H) expression levels post-ATI and blood CD8+ T-cell-mediated SIV-suppressive activity AUC post-ATI. (A-H) Individual data are shown (n = 6 animals per group); (B–D, F, G) Medians are shown; *p < 0.05, **p < 0.01; ***p < 0.001; ns non-significant; Two sided Mann‒Whitney U test. Source data are provided as a Source Data file.

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