Fig. 1: The biosynthesis of ajmaline.
From: De novo biosynthesis of antiarrhythmic alkaloid ajmaline
The enzymes in magenta are discovered and characterized in this study. STR strictosidine synthase, SGD strictosidine β-glucosidase, GS geissoschizine synthase, SBE1 and SBE2 sarpagan bridge enzyme, PNAE polyneuridine aldehyde esterase, VS vinorine synthase, VH vinorine hydroxylase, VR vomilenine 1,2(R)-reductase, DHVR 1,2-dihydrovomilenine 19,20(S)-reductase, AAE, AAE1, and AAE2 17-O-acetylnorajmaline acetyl esterase, NNMT norajmaline N-methyltransferase.
