Fig. 8: The working model showing zebrafish Cebps in balancing granulopoiesis. | Nature Communications

Fig. 8: The working model showing zebrafish Cebps in balancing granulopoiesis.

From: Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish

Fig. 8

HSC or myeloid progenitor (MP) undergo stepwised differentiation for granulopoiesis. The neutrophil lineage cells contain proNeu1, proNeu2, pre.Neu, and mat.Neu, which nomenclature is based on a previous study39. The eosinophil lineage cells contain Eb-P, EoP, pre.Eos, and mat.Eos. For granulopoiesis, Cebp1 is essential for the generation of the neutrophil lineage, and Cebp1 suppresses Cebpβ to inhibit the commitment and differentiation of the eosinophil lineage.

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