Fig. 4: DTMS improving positively remodeling rat ventricle after MI.
From: Two way workable microchanneled hydrogel suture to diagnose, treat and monitor the infarcted heart
a 2D and M-mode echocardiography on day 28. b Survival rate of each group in 1 month. c–e Cardiac function of each group. Quantitative analysis of Left Ventricular Diastolic Dysfunction (LVDd) c, Left Ventricular Systolic Dimension (LVDs) d, and Left Heart Ejection Fraction (LVEF) e evaluated by echocardiography on days 0, 7, 14, 28. N = 5 biologically independent replicates. Two-way ANOVA with multiple comparison tests. All values are presented as mean ± SD. ####P < 0.0001 ###P < 0.001, ##P < 0.01 and #P < 0.05, S-DTMS compared with MI group. ****P < 0.0001 and ***P < 0.001, **P < 0.01 and *P < 0.05, S-DTMS compared with DTMS group. ++++P < 0.0001 and +++P < 0.001, ++P < 0.01 and +P < 0.05, S-DTMS compared with Normal group. f (i) Gross images of the heart. (ii) Section Masson staining, (iii) Sliced H&E staining. (iv) a-SMA staining. g Positron emission computed tomography (PET-CT) images in cardiac long-axis and short axis on day 28. N = 3 biologically independent replicates. h Standardized uptake value (SUV) of cardiomyocytes. One-way ANOVA with multiple comparison tests. All values are presented as mean ± SD. N = 3 biologically independent replicates. i, j Quantitative analysis of left ventricular wall thickness i and myocardial fibrosis area j of rats after 1 month. i, j One-way ANOVA with multiple comparison tests. All values are presented as mean ± SD. N = 8 biologically independent replicates.
