Fig. 9: Pre-exposure to phage cocktail results in re-sensitisation to antibiotics in vivo. | Nature Communications

Fig. 9: Pre-exposure to phage cocktail results in re-sensitisation to antibiotics in vivo.

From: Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

Fig. 9

Bacterial colony forming units (CFU) in P. aeruginosa infected mice after treatment with either PBS or phage cocktail at 5 h post bacterial infection, and treatment with either phosphate buffered saline (PBS), meropenem, or tobramycin at 48 h post bacterial infection. a–e CFU in the lung, liver, blood, kidney, and spleen 72 h post bacterial infection. Treatment groups include PBS (black), phage cocktail (dark purple), tobramycin (green), meropenem (pink), phage cocktail and meropenem (light purple) and phage cocktail and tobramycin (light blue). Each symbol represents an individual mouse and line indicates the mean. Results are combination of two independent experiments, n = 10 mice per group per timepoint. Significant difference in CFU between PBS & tobramycin and phage cocktail & tobramycin treated mice was observed in the lung (p = 0.0238). Significant differences in CFU between PBS & meropenem and phage cocktail & meropenem treated mice were seen in the liver (p = 0.0133) and kidney (p = 0.0046). The y-axis has been corrected by adding 1 (to zero all samples). Statistics were performed using a one-way ANOVA Bonferroni correction **p < 0.01 *p < 0.05. Source data are provided as a Source Data file.

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