Fig. 6: Medications- and diet-associated ileal viral species.

a Medications-associated ileal viral species. Associations between viral species and medications were identified via MaAsLin2 controlling for remission/flare-up, dietary habit, and geography. Only the significant associations (BH-FDR q < 0.2 [p < 0.05]) were plotted via bubble plot. The red bubbles indicate species with a positive association with medications, and blue bubbles indicate species with an inverse association with medications. The bubble shading intensity indicates the magnitude of the association between viral species and medications. The bubble size indicates the prevalence rate of the viral species across study participants. The associations of these viral species with CD were also plotted for comparative visualisation. Statistical significance was determined by a two-tailed multivariable association test, adjusted by the BH-FDR adjustment. b Diet-associated ileal viral species.