Fig. 2: Chemical synthesis of Homo-BacPROTACs.
From: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria
a Chemical synthesis of exit vector 6 Homo-BacPROTACs via CuAAC. b Synthesis of exit vector 7 Homo-BacPROTACs via CuAAC. c Synthesis of exit vector 6 and 3 Homo-BacPROTACs via olefin metathesis. BEP: 2-Bromo-1-ethylpyridinium tetrafluoroborate; DMBA: N,N’-Dimethylbarbituric acid; EDC: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt: 1-Hydroxybenzotriazole; NMM: N-methylmorpholine; TPPTS: 3,3’,3”-Phosphanetriyltris(benzenesulfonic acid) trisodium salt; HATU: 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate.
