Fig. 3: Neurogenic skeletal muscular atrophy in both Mut and Del mice.
From: PCDHA9 as a candidate gene for amyotrophic lateral sclerosis
a The sizes and weights of gastrocnemius muscles from 13-month old mice. Data represent mean ± SEM. one-way ANOVA. n = 6 in WT and Del, n = 4 in Mut, n represents biologically independent replicates. b H&E staining of gastrocnemius muscles from 14-month-old mice. Black arrows: atrophied muscle fibers. Red arrows: centrally localized nuclei. White frame indicates the enlarged area. Scale bar: 50 μm in low power image, 10 μm in enlarged image. 3 biological repeats showed the same results. c Denervative potentials detected in multiple skeletal muscles in Mut mice. Left panel: Positive sharp waves (PSWs) in the left shoulder-deltoid muscle (SDM) and the right gastrocnemius muscle (GAS), and fibrillation potentials (FPs) detected in the left trapezius dorsi muscle (TDM) and spontaneous motor unit potential and FPs in right rectus femoris muscle (RFM). Right panel: Heatmap of the distribution of denervative potentials (13-month-old mice, n = 4). Total number of PSWs and FPs for all four quadrants of a muscle were counted and indicated. L: left; R: right., BRM: biceps brachii muscle; RAM: rectus abdoininis muscle. Source data are provided as a source data file.
