Fig. 4: Human MRP2 activity is reduced by kinase inhibition in hepatocyte-like cells.
From: Structural basis for the modulation of MRP2 activity by phosphorylation and drugs
a Live cell imaging of CDF (green) accumulation in the bile canaliculi of iHEPs. Nuclei are stained with Hoechst 33342 (blue). Single grayscale images and merged multicolour images are shown. b Integrated density image analysis shows a 50% reduction in CDF transport into the canaliculi upon treatment with staurosporine. Results are represented as means from 4 iHEP batches (n = 3 images per condition per batch). Significantly different as estimated by one-tail paired t-test (p = 8.01 × 10−4). Source data are provided as a Source Data file.
