Fig. 2: Lipid molecules within the middle ___domain of Doa10 and the flexibility of the RING-CH ___domain. | Nature Communications

Fig. 2: Lipid molecules within the middle ___domain of Doa10 and the flexibility of the RING-CH ___domain.

From: Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

Fig. 2

a Lipid molecules entrapped in the interior of the TMD. The orientation of the Doa10 model (viewed from the cytosol) is rotated by ~90° clockwise from Fig. 1b. b As in (a), but a lateral view from the central cavity to the middle ___domain. c An AlphaFold2 model of the RING-CH and CTE domains. Shown is a side view, equivalent to view in (d) and Fig. 1f. d Result of an MD simulation on WT Doa10 (side view). Positional flexibility of RING-CH is represented with multiple overlaid structures.

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