Fig. 8: Determining the developmental window during which de novo ERVK mobilization occurs from the frequency distribution of resampling rate.

a Number of de novo insertions captured 1x, 2x, 3x, 4x and >4x for real data (darkest grey) and data simulated using the developmental windows shown in (b). b Stacked distributions of de novo mobilization rate at various cell generations of spermatogenesis (1 to 21, i.e. 20 cell divisions generating 2²⁰ = 1,048,576 “spermatogonial stem cells” from one ancestral primordial germ cell) that maximize the correspondence between simulated and real number and resampling rate of captured de novo insertions. Dark grey: 5-generation window; Grey: 7-generation window; Light grey: 9-generation window. The three window-sizes, when centered on cell generation 14, matched the real data (nearly) equally well (Supplementary Data 13). Source data are provided as a Source Data file.